The present paper addresses the study of non-arbitrariness in language within a deep learning framework. We present a set of experiments aimed at assessing the pervasiveness of different forms of non-arbitrary phonological patterns across a set of typologically distant languages. Different sequence-processing neural networks are trained in a set…

Background: Although long-term social challenges following traumatic brain injury (TBI) are well documented, the challenges of establishing new relationships following TBI are less understood. Aims: To examine how the type of non-verbal cues produced by an unfamiliar communication partner impacts feelings of relationship closeness by people with…

The amygdalo-nigrostriatal (ANS) network plays an essential role in enhanced attention to significant events. Interval timing requires attention to temporal cues. We assessed rats having a disconnected ANS network, due to contralateral lesions of the medial central nucleus of the amygdala (CEm) and dopaminergic afferents to the lateral striatum,…

A key index of top-down control in task switching--preparation for a switch--is underexplored in language switching. The well-documented EEG "signature" of preparation for a task switch--a protracted positive-polarity modulation over the posterior scalp--has thus far not been reported in language switching, and the interpretation of…

The neural mechanisms that underlie familiarity memory have been extensively investigated, but a consensus understanding remains elusive. Behavioral evidence suggests that familiarity sometimes shares sources with instances of implicit memory known as priming, in that the same increases in processing fluency that give rise to priming can engender…

Remembering the past and envisioning the future are at the core of one's sense of identity. Neuroimaging studies investigating the neural substrates underlying past and future episodic events have been growing in number. However, the experimental paradigms used to select and elicit episodic events vary greatly, leading to disparate results,…

Maltreating mothers often struggle to respond sensitively to their children's distress. Examining psychophysiological processing of own child cues may offer insight into neurobiological mechanisms that promote sensitive parenting among high-risk mothers. The current study used event-related potential (ERP) methodology to examine associations…

Alpha circuits (8-12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha…

This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects…

The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are unclear. Considerable evidence indicates that coactivator of transcription and histone acetyltransferase cAMP response element binding protein (CREB) binding protein (CBP) is critically required…

Functional magnetic resonance imaging was used to examine functional anatomy of attention to social (eye gaze) and nonsocial (arrow) communicative stimuli in late childhood and in a disorder defined by atypical processing of social stimuli, Autism Spectrum Disorders (ASD). Children responded to a target word ("LEFT"/"RIGHT") in the context of a…

To directly address whether regulating mRNA localization can influence animal behavior, we created transgenic mice that conditionally express Zipcode Binding Protein 1 (ZBP1) in a subset of neurons in the brain. ZBP1 is an RNA-binding protein that regulates the localization, as well as translation and stability of target mRNAs in the cytoplasm. We…

The most important information conveyed by language is often contained not in the utterance itself, but in the interaction between the utterance and the comprehender's knowledge of the world and the current situation. This dissertation uses psycholinguistic methods to explore the effects of a common type of inference--causal inference--on language…

Event-related brain potentials (ERPs) were recorded during a Chinese character decision task to examine whether N400 amplitude is modulated by stimulus font. Results revealed large negative-going ERPs in an N400 time window of 300-500 ms to stimuli presented in degraded Xing Kai Ti (XKT) font compared with more intact Song Ti (ST) font regardless…

Recent studies have demonstrated that central cues, such as eyes and arrows, reflexively trigger attentional shifts. However, it is not clear whether the attentional mechanisms induced by these two cues are similar or rather differ in some important way. We investigated hemispheric lateralization of the orienting effects induced by the two cue…