A substantial proportion of trial registrations are not linked to corresponding published articles, limiting analyses and new tools. Our aim was to develop a method for finding articles reporting the results of trials that are registered on ClinicalTrials.gov when they do not include metadata links. We used a set of 27,280 trial registration and…

Introduction: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination of results, and the prevalence of consistency in hypothesis, sample size, and primary endpoint of Dutch…

Randomised trials are often funded by commercial companies and methodological studies support a widely held suspicion that commercial funding may influence trial results and conclusions. However, these studies often have a risk of confounding and reporting bias. The risk of confounding is markedly reduced in meta-epidemiological studies that…

Background: Both PubMed and Ovid MEDLINE contain records from the MEDLINE database. However, there are subtle differences in content, functionality, and search syntax between the two. There are many instances in which researchers may wish to search both interfaces, such as when conducting supplementary searching for a systematic review to retrieve…

Introduction: Registration and publication of trial protocols has become increasingly important and a requirement in some sources of funding and publication. Increased access to protocols yields many potential benefits, but there are issues regarding identification of published protocols. The aim of this investigation is to compare methods of…

Background: It has been reported that information sources searched in systematic reviews (SRs) are insufficiently comprehensive. We analyzed information sources used in SRs, as well as how up-to-date were the searches. Methods: We searched PubMed and the Cochrane Database of Systematic Reviews (CDSR) through Wiley from 2012 to 2016 to find SRs of…

Objective: Identify the most performant automated text classification method (eg, algorithm) for differentiating empirical studies from nonempirical works in order to facilitate systematic mixed studies reviews. Methods: The algorithms were trained and validated with 8050 database records, which had previously been manually categorized as…

In meta-analysis, the random-effects model is often used to account for heterogeneity. The model assumes that heterogeneity has an additive effect on the variance of effect sizes. An alternative model, which assumes multiplicative heterogeneity, has been little used in the medical statistics community, but is widely used by particle physicists. In…

When the Medical Library Association identified questions critical for the future of the profession, it assigned groups to use systematic reviews to find the answers to these questions. Group 6, whose question was on emerging technologies, recognized early on that the systematic review process would not work well for this question, which looks…

Assesses the impact of current coverage and indexing policies on MEDLINE's retrieval performance in the medical behavioral sciences literature by comparing retrievals in EXCERPTA MEDICA, PSYCHINFO, SCISEARCH, and SOCIAL SCISEARCH. Searches were made with descriptors, cited references, and natural language, and recall, precision, and novelty ratios…