Population-adjusted indirect comparisons, developed in the 2010s, enable comparisons between two treatments in different studies by balancing patient characteristics in the case where individual patient-level data (IPD) are available for only one study. Health technology assessment (HTA) bodies increasingly rely on these methods to inform funding…

Reference intervals, or reference ranges, aid medical decision-making by containing a pre-specified proportion (e.g., 95%) of the measurements in a representative healthy population. We recently proposed three approaches for estimating a reference interval from a meta-analysis based on a random effects model: a frequentist approach, a Bayesian…

Background: Model-based meta-analysis (MBMA) is increasingly used to inform drug-development decisions by synthesising results from multiple studies to estimate treatment, dose-response, and time-course characteristics. Network meta-analysis (NMA) is used in Health Technology Appraisals for simultaneously comparing effects of multiple treatments,…

The global COVID-19 pandemic has had a considerable impact on the scientific enterprise, including scholarly publication and peer-review practices. Several studies have assessed these impacts, showing among others that medical journals have strongly accelerated their review processes for COVID-19-related content. This has raised questions and…

One of the challenges humans face is making collective decisions with regards to controversial issues related to science, namely socio-scientific issues (SSIs). Genetic modification, nuclear energy, experimental drugs, 5G technology are a few examples of SSIs. Some of the concerns posed by such issues are compromise to privacy and identity, threat…

The goal of education and research in all disciplines is to develop critical thinking skills as a method for improving clinical decisionmaking. The emphasis on critical thinking is nothing new and can be traced back to ancient times when Socrates challenged his students to think about their knowledge, beliefs, and behaviors by interrogating them.…

In recent years the scope and application of intellectual property rights has been expanded remarkably in the area of medical research and development. This has strengthened the role of the private sector in developing and producing new medicinal drugs. However, medical research is usually close to a pure public good and thus not efficiently…

Health science (epidemiology) is a relatively advanced discipline which offers theories and methods which could be useful in peace science (polemology). Similarities between war and disease, peace and health, center around concern with prevention of physical damage and death on the one hand and preservation and extension of human life on the…

An empirical study of the nature and variability of the relevance judgment process was conducted from July 1, 1965 to September 30, 1967. Volume I of the final report presents a literature review and statement of the theoretical framework of the study, a discussion of the experimental design and a summary of data analyses. The study had two…

This volume consists of appendices to the final report on a study of the nature and variability of relevance judgments connected with document searching. Included in these appendices are: (1) all test materials and forms used in the experiments with medical librarians, medical experts, medical scientists, and medical students who were asked to…