Youth mental health concerns are on the rise and can have serious implications for student well-being and success (Clayborne et al., 2019). Consequently, more educators and mental health professionals are identifying mental health as an important student need (American Academy of Pediatrics, 2021). This report summarizes the key principles underlying comprehensive school mental health and trauma sensitive schools. The present synthesis of studies and reports emphasizes core features, key principles, and associated core components. [This report was co-produced by the Wisconsin Evaluation Collaborative and originally prepared for the Wisconsin Department of Public Instruction (DPI).]