Background: Clustered randomized controlled trials are commonly used to evaluate the effectiveness of treatments. Frequently, stratified or paired designs are adopted in practice. Fogarty (2018) studied variance estimators for stratified and not clustered experiments and Schochet et. al. (2022) studied that for stratified, clustered RCTs with…

When planning a cluster randomized trial, evaluators often have access to an enumerated cohort representing the target population of clusters. Practicalities of conducting the trial, such as the need to oversample clusters with certain characteristics in order to improve trial economy or support inferences about subgroups of clusters, may preclude…

The purpose of this dissertation is to develop principles and strategies for and identify limitations of multisite cluster randomized trials in the context of partially and fully nested designs. In the first study, I develop principles of estimation, sampling variability, and inference for studies that leverage multisite designs within the context…

Evaluating blocked randomized experiments from a potential outcomes perspective has two primary branches of work. The first focuses on larger blocks, with multiple treatment and control units in each block. The second focuses on matched pairs, with a single treatment and control unit in each block. These literatures not only provide different…

Conventionally, regression discontinuity analysis contrasts a univariate regression's limits as its independent variable, "R," approaches a cut point, "c," from either side. Alternative methods target the average treatment effect in a small region around "c," at the cost of an assumption that treatment assignment,…

In the causal inference literature, evaluating blocking from a potential outcomes perspective has two main branches of work. The first focuses on larger blocks, with multiple treatment and control units in each block. The second focuses on matched pairs, with a single treatment and control unit in each block. These literatures not only provide…

When a multisite randomized trial reveals between-site variation in program impact, methods are needed for further investigating heterogeneous mediation mechanisms across the sites. We conceptualize and identify a joint distribution of site-specific direct and indirect effects under the potential outcomes framework. A method-of-moments procedure…