Cyberattacks pose a significant threat to university institutions as universities increasingly rely on computer networks to conduct day-to-day business activities. University information technology (IT) leaders are concerned about the increasing level of cyberattacks because these attacks can result in the loss of sensitive data, identity theft, and derivative costs. Grounded in systems theory, the purpose of this qualitative pragmatic inquiry was to explore strategies IT leaders of universities in Cameroon use to prevent or mitigate the costs of cyberattacks. The participants were eight IT leaders of universities in Cameroon with at least five years of experience in cybersecurity management and who successfully implemented effective strategies to prevent or mitigate the costs of cyberattacks. Data were collected using semistructured interviews and analyzed using thematic analysis. Three key themes emerged: employing multiple strategies to prevent or mitigate the cost of cyberattacks, incorporating educational training programs, and adopting security policies and procedures for best practices to ensure business continuity. A key recommendation is for university IT leaders to conduct regular cybersecurity awareness training, focusing on patient prevention, password security, and engineering social engineering awareness. The implication for positive social change is the potential to enhance cybersecurity measures and improve business viability and job creation, positively impacting the local communities and tax revenues. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]