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Direct linkPapadimitropoulou, Katerina; Stijnen, Theo; Dekkers, Olaf M.; le Cessie, Saskia – Research Synthesis Methods, 2019
The vast majority of meta-analyses uses summary/aggregate data retrieved from published studies in contrast to meta-analysis of individual participant data (IPD). When the outcome is continuous and IPD are available, linear mixed modelling methods can be employed in a one-stage approach. This allows for flexible modelling of within-study…
Descriptors: Meta Analysis, Outcome Measures, Hierarchical Linear Modeling, Sample Size
Günhan, Burak Kürsad; Röver, Christian; Friede, Tim – Research Synthesis Methods, 2020
Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number of studies is low, standard random-effects meta-analysis methods can lead to serious distortions because of such data sparsity. To overcome this, we suggest the use of…
Descriptors: Meta Analysis, Medical Research, Drug Therapy, Bayesian Statistics
