In this article, the author describes his experience when Kathy Nichols contacted him seeking suggestions, recommendations--really anything he could think of--that might help her seize control of a bewildering and rapidly surging torrent of digital image files. The challenges that Nichols described interested him, and he felt they might be…

Organized from the viewpoint of information retrieval theory, this review addresses issues of chemical information representation, comparison and matching, and retrieval strategies. Additional topics include similarity and clustering, visualization, and molecular diversity. Trends in research and application are identified, and gaps in the…