Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus…

The central amygdala nucleus (CeA) plays a critical role in cognitive processes beyond fear conditioning. For example, intact CeA function is essential for enhancing attention to conditioned stimuli (CSs). Furthermore, this enhanced attention depends on the CeA's connections to the nigrostriatal system. In the current study, we examined the role…

In experiments that measured food consumption, Holland (1981; "Learning and Motivation," 12, 1-18) found that food aversions were formed when an exteroceptive associate of food was paired with illness, but not when such an associate was paired with shock. By contrast, measuring the ability of food to reinforce instrumental responding,…

A simple extension of a network model of conditioning developed by N. Schmajuk and J. Di Carlo (1992) is applied to descriptions of two different conditioned stimulus (CS) functions: (1) a simple CS eliciting conditioned responses by signaling the occurrence of an unconditioned stimulus; and (2) an occasion setter controlling the responses…

Rat received conditioning based upon a food unconditioned stimulus and then received manipulations designed to reduce the value of that food. The effects of these manipulations were assessed during extinction tests of the conditioned stimuli. (Editor/RK)

Recent data indicate that the form of the conditioned response (CR) may often be substantially influenced by the characteristics of the conditioned stimulus (CS) as well as by those of the unconditioned stimulus (US). Here five experiments examine the influence of CS characteristics on the form of the Pavlovian CR anticipatory to a food US in…