There is little evidence regarding the impact of helicopter parenting (HP) on adolescents' school adjustment (SA). This study examined gender differences in maternal/paternal HP, internal/external academic locus of control (ALC) and SA, and the mediating effect of internal/external ALC in the relationship between maternal/paternal HP and SA in adolescents. The participants of the study were 447 adolescents. The results revealed no significant gender differences in study variables except for external ALC. Adolescent boys indicated significantly higher levels of external ALC than girls. HP predicted ALC and SA, and internal/external ALC had a mediating role in the relationship between HP and SA. This study provides important insights for researchers and practitioners seeking to understand the effects of maternal/paternal HP on adolescent SA. The results of our study suggest that HP may be associated with lower SA among adolescents and that internal ALC may be a key mechanism in this relationship.