A high percentage of students enter college with prior trauma, and trauma-informed practices are increasingly recognized as valuable in higher education. We examined if the tone of a syllabus would interact with levels of trauma or stress to impact participants' perceptions of the instructor, willingness to seek help, and self-efficacy. We tested a 2 (tone: warm vs. cold) X 2 (trauma: low vs. high) experimental design and a 2 (tone: warm vs. cold) X 2 (stress: low vs. high) experimental design. We recruited current college students and asked them to read a syllabus for a hypothetical class, which varied in tone. Students indicated their willingness to communicate with the instructor, as well as perceptions of their classroom self-efficacy and instructor attributes. Students then responded to scales that assessed their current stress and past trauma. Results revealed that in the high trauma condition, students attributed the most positive attributes to the warm-syllabus instructor and the most negative attributes to the cold-syllabus instructor. Student trauma did not interact with syllabus tone to predict perceived self-efficacy or willingness to communicate. Student stress did not interact with syllabus tone to predict instructor attributes or perceived self-efficacy; however, in the warm condition, high stress students revealed the greatest willingness to communicate with the instructor. The use of a warm syllabus as a tool to create a supportive learning environment may benefit all college students, but particularly those experiencing high levels of stress or trauma.