This study examines the media literacy and critical thinking levels of students of West African higher educational institutions as tools for combating misinformation in the sub-region. Data analysis using the mediation approach revealed differences in students' understanding of media literacy and critical thinking and partially predicted their efficacy in combating misinformation. This stems largely from a misunderstanding of media literacy and critical thinking concepts as tools, as well as a lack of adequate provision for teaching the concepts and considering them as strategic tools for combating misinformation in the region. The study recommends concrete policy and managerial solutions to the stakeholders involved.