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Direct linkOstroff, Linnaea E.; Cain, Christopher K. – Learning & Memory, 2022
Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are…
Descriptors: Long Term Memory, Associative Learning, Brain, Cognitive Processes
Lazzaro, Stephanie C.; Hou, Mian; Cunha, Catarina; LeDoux, Joseph E.; Cain, Christopher K. – Learning & Memory, 2010
Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued fear conditioning. Systemic or intra-lateral amygdala…
Descriptors: Posttraumatic Stress Disorder, Conditioning, Long Term Memory, Fear
Kelley, Jonathan B.; Balda, Mara A.; Anderson, Karen L.; Itzhak, Yossef – Learning & Memory, 2009
The fear conditioning paradigm is used to investigate the roles of various genes, neurotransmitters, and substrates in the formation of fear learning related to contextual and auditory cues. In the brain, nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) functions as a retrograde neuronal messenger that facilitates synaptic…
Descriptors: Animals, Cues, Scientific Research, Conditioning
