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Direct linkDarvas, Martin; Fadok, Jonathan P.; Palmiter, Richard D. – Learning & Memory, 2011
Two-way active avoidance (2WAA) involves learning Pavlovian (association of a sound cue with a foot shock) and instrumental (shock avoidance) contingencies. To identify regions where dopamine (DA) is involved in mediating 2WAA, we restored DA signaling in specific brain areas of dopamine-deficient (DD) mice by local reactivation of conditionally…
Descriptors: Animals, Classical Conditioning, Genetics, Biochemistry
Theberge, Florence R. M.; Milton, Amy L.; Belin, David; Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2010
A distributed limbic-corticostriatal circuitry is implicated in cue-induced drug craving and relapse. Exposure to drug-paired cues not only precipitates relapse, but also triggers the reactivation and reconsolidation of the cue-drug memory. However, the limbic cortical-striatal circuitry underlying drug memory reconsolidation is unclear. The aim…
Descriptors: Cues, Cocaine, Symptoms (Individual Disorders), Classical Conditioning
