Compared to women, men are less likely to become occupational therapists (OT). To have a more diverse workforce, and to relate to various patient groups, reasons men do not enter the field of OT must be better understood. Our study compares men and women in their familiarity with OT and desire to work in the field. Data were gathered using an online, self-report survey administered to students at a public university in the southeast. The sample included 334 undergraduate students who were in majors that often serve as feeder programs to OT graduate programs. The average age was 19.8 years (SD = 3.84). A majority of the students were women (80.1%). Ratings of familiarity with OT or interest in OT were generally low, with no significant differences between men and women. Women were more likely to endorse a calling orientation (i.e., work brings fulfillment to life) to their work, while men were more likely to endorse a career (i.e., advancement indicates achievement) or job orientation (i.e., the job is a means to an end). Career orientation predicted a greater interest in entering healthcare for men, but not women. More broadly, men and women may be interested in healthcare for different reasons, and this information needs to be utilized in marketing the profession.