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The Bi-Directional Relationship between Parent-Child Conflict and Treatment Outcome in Treatment-Resistant Adolescent Depression
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Rengasamy, Manivel; Mansoor, Brandon M.; Hilton, Robert; Porta, Giovanna; He, Jiayan; Emslie, Graham J.; Mayes, Taryn; Clarke, Gregory N.; Wagner, Karen Dineen; Keller, Martin B.; Ryan, Neal D.; Birmaher, Boris; Shamseddeen, Wael; Asarnow, Joan Rosenbaum; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To examine the bidirectional relationship between parent-child discord and treatment outcome for adolescent treatment-resistant depression. Method: Depressed youth who had not responded to an adequate course of a selective serotonin reuptake inhibitor (SSRI) were randomized to either a switch to another SSRI or venlafaxine, with or…
Descriptors: Behavior Modification, Therapy, Adolescents, Parents
Anhedonia Predicts Poorer Recovery among Youth with Selective Serotonin Reuptake Inhibitor Treatment-Resistant Depression
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McMakin, Dana L.; Olino, Thomas M.; Porta, Giovanna; Dietz, Laura J.; Emslie, Graham; Clarke, Gregory; Wagner, Karen Dineen; Asarnow, Joan R.; Ryan, Neal D.; Birmaher, Boris; Shamseddeen, Wael; Mayes, Taryn; Kennard, Betsy; Spirito, Anthony; Keller, Martin; Lynch, Frances L.; Dickerson, John F.; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: To identify symptom dimensions of depression that predict recovery among selective serotonin reuptake inhibitor (SSRI) treatment-resistant adolescents undergoing second-step treatment. Method: The Treatment of Resistant Depression in Adolescents (TORDIA) trial included 334 SSRI treatment-resistant youth randomized to a medication…
Descriptors: Outcomes of Treatment, Rating Scales, Adolescents, Depression (Psychology)
Impact of Physical and Sexual Abuse on Treatment Response in the Treatment of Resistant Depression in Adolescent Study (TORDIA)
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Shamseddeen, Wael; Asarnow, Joan Rosenbaum; Clarke, Gregory; Vitiello, Benedetto; Wagner, Karen Dineen; Birmaher, Boris; Keller, Martin B.; Emslie, Graham; Iyengar, Satish; Ryan, Neal D.; McCracken, James T.; Porta, Giovanna; Mayes, Taryn; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: We previously reported that a history of abuse was associated with a poorer response to combination treatment in the Treatment of Resistant Depression in Adolescents study (TORDIA). We now report on the nature and correlates of abuse that might explain these findings. Method: Youth who did not benefit from an adequate selective…
Descriptors: Sexual Abuse, Adolescents, Therapy, Depression (Psychology)
Treatment-Resistant Depressed Youth Show a Higher Response Rate If Treatment Ends during Summer School Break
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Shamseddeen, Wael; Clarke, Gregory; Wagner, Karen Dineen; Ryan, Neal D.; Birmaher, Boris; Emslie, Graham; Asarnow, Joan Rosenbaum; Porta, Giovanna; Mayes, Taryn; Keller, Martin B.; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: There is little work on the effect of school on response to treatment of depression, with available research suggesting that children and adolescents with school difficulties are less likely to respond to fluoxetine compared with those with no school difficulties. Method: Depressed adolescents in the Treatment of Resistant Depression in…
Descriptors: Adolescents, Vacations, Depression (Psychology), Counseling Effectiveness
Pharmacokinetically and Clinician-Determined Adherence to an Antidepressant Regimen and Clinical Outcome in the TORDIA Trial
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Woldu, Hiwot; Porta, Giovanna; Goldstein, Tina; Sakolsky, Dara; Perel, James; Emslie, Graham; Mayes, Taryn; Clarke, Greg; Ryan, Neal D.; Birmaher, Boris; Wagner, Karen Dineen; Asarnow, Joan Rosenbaum; Keller, Martin B.; Brent, David – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Nonadherence to antidepressant treatment may contribute to poor outcome and to suicidal adverse events in adolescent depression. We examine the relationship between adherence and both clinical response and suicidal events in participants in the Treatment of Resistant Depression in Adolescents (TORDIA) study. Method: The relationship…
Descriptors: Evidence, Suicide, Cognitive Restructuring, Adolescents
Sleep Items in the Child Behavior Checklist: A Comparison with Sleep Diaries, Actigraphy, and Polysomnography
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Gregory, Alice M.; Cousins, Jennifer C.; Forbes, Erika E.; Trubnick, Laura; Ryan, Neal D.; Axelson, David A.; Birmaher, Boris; Sadeh, Avi; Dahl, Ronald E. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: The Child Behavior Checklist is sometimes used to assess sleep disturbance despite not having been validated for this purpose. This study examined associations between the Child Behavior Checklist sleep items and other measures of sleep. Method: Participants were 122 youth (61% female, aged 7 through 17 years) with anxiety disorders…
Descriptors: Anxiety Disorders, Check Lists, Sleep, Child Behavior
Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression from Bipolar Disorder Not Otherwise Specified
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Axelson, David A.; Birmaher, Boris; Strober, Michael A.; Goldstein, Benjamin I.; Ha, Wonho; Gill, Mary Kay; Goldstein, Tina R.; Yen, Shirley; Hower, Heather; Hunt, Jeffrey I.; Liao, Fangzi; Iyengar, Satish; Dickstein, Daniel; Kim, Eunice; Ryan, Neal D.; Frankel, Erica; Keller, Martin B. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: To determine the rate of diagnostic conversion from an operationalized diagnosis of bipolar disorder not otherwise specified (BP-NOS) to bipolar I disorder (BP-I) or bipolar II disorder (BP-II) in youth over prospective follow-up and to identify factors associated with conversion. Method: Subjects were 140 children and adolescents…
Descriptors: Intervals, At Risk Persons, Adolescents, Mental Disorders
Daily Emotional Dynamics in Depressed Youth: A Cell Phone Ecological Momentary Assessment Study
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Silk, Jennifer S.; Forbes, Erika E.; Whalen, Diana J.; Jakubcak, Jennifer L.; Thompson, Wesley K.; Ryan, Neal D.; Axelson, David A.; Birmaher, Boris; Dahl, Ronald E. – Journal of Experimental Child Psychology, 2011
This study used a new cell phone ecological momentary assessment approach to investigate daily emotional dynamics in 47 youths with major depressive disorder (MDD) and 32 no-psychopathology controls (CON) (ages 7-17 years). Information about emotional experience in the natural environment was obtained using answer-only cell phones, while MDD…
Descriptors: Emotional Response, Access to Information, Drug Therapy, Psychopathology
Objective Sleep in Pediatric Anxiety Disorders and Major Depressive Disorder
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Forbes, Erika E.; Bertocci, Michele A.; Gregory, Alice M.; Ryan, Neal D.; Axelson, David A.; Birmaher, Boris; Dahl, Ronald E. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
A study to examine sleep problems encountered in anxiety and depressive disorders among children and adolescents is conducted. Results indicated subjective and objective sleep problems in children and adolescents with anxiety disorders and need to be kept in mind when treating young anxious people.
Descriptors: Sleep, Adolescents, Children, Anxiety
Healthy Adolescents' Neural Response to Reward: Associations with Puberty, Positive Affect, and Depressive Symptoms
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Forbes, Erika E.; Ryan, Neal D.; Phillips, Mary L.; Manuck, Stephen B.; Worthman, Carol M.; Moyles, Donna L.; Tarr, Jill A.; Sciarrillo, Samantha R.; Dahl, Ronald E. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Changes in reward-related behavior are an important component of normal adolescent affective development. Understanding the neural underpinnings of these normative changes creates a foundation for investigating adolescence as a period of vulnerability to affective disorders, substance use disorders, and health problems. Studies of…
Descriptors: Adolescents, Brain, Rewards, Puberty
Expressed Emotion in Mothers of Currently Depressed, Remitted, High-Risk, and Low-Risk Youth: Links to Child Depression Status and Longitudinal Course
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Silk, Jennifer S.; Ziegler, Melissa L.; Whalen, Diana J.; Dahl, Ronald E.; Ryan, Neal D.; Dietz, Laura J.; Birmaher, Boris; Axelson, David A.; Williamson, Douglas E. – Journal of Clinical Child and Adolescent Psychology, 2009
This study examined expressed emotion in the families of children and adolescents who were (a) in a current episode of Major Depressive Disorder (MDD), (b) in remission from a past episode of MDD, (c) at high familial risk for developing MDD, and (d) low-risk controls. Participants were 109 mother-child dyads (children ages 8-19). Expressed…
Descriptors: Mothers, Depression (Psychology), Emotional Response, Psychological Patterns
A Longitudinal Study of Childhood Depression and Anxiety in Relation to Weight Gain
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Rofey, Dana L.; Kolko, Rachel P.; Iosif, Ana-Maria; Silk, Jennifer S.; Bost, James E.; Feng, Wentao; Szigethy, Eva M.; Noll, Robert B.; Ryan, Neal D.; Dahl, Ronald E. – Child Psychiatry and Human Development, 2009
Adult mood disturbances are highly correlated with obesity, although little is known about the developmental relationship between mood disorders and weight. This study investigated the relationship between childhood psychopathology and weight over the course of 3 years. Body Mass Index (BMI) percentiles and demographic data of children (ages 8-18)…
Descriptors: Obesity, Body Composition, Females, Psychopathology
Mother-Child Interactions in Depressed Children and Children at High Risk and Low Risk for Future Depression
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Dietz, Laura J.; Birmaher, Boris; Williamson, Douglas E.; Silk, Jennifer S.; Dahl, Ronald E.; Axelson, David A.; Ehmann, Mary; Ryan, Neal D. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
A study to investigate the differences in mother and child interactions of depressed children and adolescents, nondepressed high-risk youths, and healthy controls was conducted. Results revealed increased family discord with depressed children whereas intermediate levels of control and disengagement were seen in families with high-risk children.
Descriptors: Mothers, Depression (Psychology), Parent Child Relationship, Adolescents
Altered Emotional Processing in Pediatric Anxiety, Depression, and Comorbid Anxiety-Depression.
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Ladouceur, Cecile D.; Dahl, Ronald E.; Williamson, Douglas E.; Birmaher, Boris; Ryan, Neal D.; Casey, B.J. – Journal of Abnormal Child Psychology, 2005
The goal of this study was to examine some of the mechanisms underlying emotion regulation in childhood affective disorders by examining the impact of distracting emotional information during performance on a working memory task ("Emotional n-back" or E-n-back). The sample included 75 children (38 girls and 37 boys) between 8 and 16 years of age…
Descriptors: Memory, Depression (Psychology), Anxiety
Clinical Presentation and Course of Depression in Youth: Does Onset in Childhood Differ from Onset in Adolescence?
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Birmaher, Boris; Williamson, Douglas E.; Dahl, Ronald E.; Axelson, David A.; Kaufman, Joan; Dorn, Lorah D.; Ryan, Neal D. – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder. Method: A group of prepubertal children (n = 46) and postpubertal adolescents (n = 22) were assessed with structured interviews for psychopathology and parental…
Descriptors: Psychiatry, Psychopathology, Adolescents, Anxiety
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