Two independent cohorts (N = 155, N = 126) of infants at high and low risk for autism spectrum disorder (ASD) were followed prospectively between 6 and 36 months of age, when n = 46 were diagnosed with ASD. Gaze to adult faces was coded--during a developmental assessment (Cohort 1) or a play interaction (Cohort 2). Across both cohorts, most…

This prospective study examined the developmental changes over time of adolescents diagnosed in toddlerhood with autism spectrum disorder and searched for child characteristics at toddlerhood that predict outcome at adolescence. The study included 65 participants who were divided into low cognitive (developmental quotient [less than] 85; N = 41)…

Purpose: The need for community-viable, evidence-based intervention strategies for toddlers with autism spectrum disorder (ASD) is a national priority. The purpose of this research forum article is to identify gaps in intervention research and needs in community practice for toddlers with ASD, incorporate published findings from a randomized…

After decades of rapid evolution and groundbreaking research, the field of early intervention can be understood within a common framework: the Developmental Systems Approach (DSA). Created by a highly influential leader in the field, Michael Guralnick, this evidence-based, relationship-oriented, family-centered framework focuses on strengthening…

Various theorists have argued for the importance of a developmental approach to studying typical development (Karmiloff-Smith, 1998; Lerner, 1996; Lerner & Hood, 1986; Masten & Cicchetti, 2010; Overton, 2014; Overton & Lerner, 2012, 2014), and there are reasons to believe that this issue is even more critical to the study of…

Adult humans process communicative interactions by recognizing that information is being communicated through speech (linguistic ability) and simultaneously evaluating how to respond appropriately (social-pragmatic ability). These abilities may originate in infancy. Infants understand how speech communicates in social interactions, helping them…

Purpose: To review and assess theory and research supporting DIR/Floortime™, a method proposed for treatment of young children with autism spectrum disorders (ASD). Methods: Published materials describing the principles of DIR/Floortime™were evaluated. Published outcome research articles were assessed for the adequacy of their design and…

This study investigated neurodevelopmental changes in sound processing by recording mismatch negativity (MMN) in response to various degrees of sound complexity in 18 mildly to moderately autistic versus 15 healthy boys aged between 6 and 15 years. Autistic boys presented with lower IQ and poor performance on a range of executive and social…

Background: Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about…

Little research has been conducted on whether deficits in developmental functioning affect the range of core symptoms for autism spectrum disorders (ASD). This study represents a first attempt to determine whether developmental level has an effect on the expression of ASD symptoms in infants and toddlers. Eight hundred and fifty-three infants were…

Gender differences in symptoms representing the triad of impairments of Autism Spectrum Disorders remain unclear. To date, the majority of research conducted on this topic has utilized samples of older children. Thus, the purpose of the current study was to utilize a sample of toddlers to investigate gender differences in symptom endorsements of…

Past research has focused on pretend play in infants with autism because it is considered an early manifestation of symbolic or imaginative thinking. Contradictory research findings have challenged the meta-representational model. The intent of this paper is to propose that pretend play is the behavioral manifestation of developing imaginative…

Retrospective studies indicate 2 major classes of autism spectrum disorder (ASD) onset: early and later, after a period of relatively healthy development. This prospective, longitudinal study examined social, language, and motor trajectories in 235 children with and without a sibling with autism, ages 6-36 months. Children were grouped as: ASD…

Autistic regression is one of the many mysteries in the developmental course of autism and pervasive developmental disorders not otherwise specified (PDD-NOS). Various definitions of this phenomenon have been used, further clouding the study of the topic. Despite this problem, some efforts at establishing prevalence have been made. The purpose of…

Autism is a strongly genetic disorder and de novo mutations may play a causal role in a relatively large percentage of individuals with the disease. It is discussed how altered development may be an important factor that forces diverse genetic vulnerabilities into common syndromic presentation in autism.