The treatment of Attention Deficit Hyperactivity Disorder is a matter of ongoing research and debate, with considerable data supporting both psychopharmacological and behavioral approaches. Researchers continue to search for new interventions to be used in conjunction with or in place of the more traditional approaches. These interventions run the…

Treatment adherence is a frequent problem in bipolar disorder, with research showing that more than 60% of bipolar patients are at least partially nonadherent to medications. Treatment nonadherence is consistently predictive of a number of negative outcomes in bipolar samples, and the discontinuation of mood stabilizers places these patients at…

Ninety-five persons receiving treatment for chronic pain were surveyed using the Spirituality and Chronic Pain Survey (SCPS). The survey included a pain assessment, a spiritual/religious practices assessment, and questions related to spiritual/religious beliefs and attitudes. Most participants reported experiencing constant, higher-level pain. The…

This authoritative volume provides state-of-the-art practices for supporting the approximately 20% of today's K-12 students who have emotional and behavioral disorders (EBD) that hinder school success. Leading experts present evidence-based approaches to screening, progress monitoring, intervention, and instruction within a multi-tiered framework.…

Nine autistic children (ages 7-14) were treated with fenfluramine hydrochloride or inactive placebo in a double-blind crossover trial. Results, while providing minimal support for the effectiveness of fenfluramine, also suggested the possibility that fenfluramine blood levels might be related to treatment response. (Author/DB)

Depression doubles the likelihood of comorbid depression, which presents as major depression in 11% and subsyndromal depression in 31% of patients with the medical illness. The course of depression is chronic, and afflicted patients suffer an average of one episode annually. Depression has unique importance in diabetes because of its association…

Akathisia, a state of uncontrollable motor restlessness, is a side effect of neuroleptic treatment. The prevalence rate of akathisia in 94 adults with mental retardation was estimated to be 5% in neuroleptic-free subjects, 17% in neuroleptic-maintenance subjects, and 25% in neuroleptic-reduction subjects. Akathisia was also related to dyskinesia…

Medicaid billing information was used to examine the administration of psychotropic medication to residents of community long-term care facilities providing mental retardation services. Results indicated 28.9 percent of such residents in Illinois received at least one psychotropic medication with little or no influence of demographic and facility…

This study evaluated effects on 77 institutionalized patients with mental retardation of changing from anticonvulsant Depakote to the similar drug, Depakene. Results showed no changes in seizure control, less lethargy on Depakene, but some increase in diarrhea and some changes in psychiatric symptoms. Substantial cost savings were achieved by the…

Evaluation of high doses of pyridoxine and magnesium in a 10-week double-blind placebo-controlled trial with 10 patients (mean age 6 years) having autism concluded that the high doses used were ineffective in ameliorating autistic behaviors. (DB)

This paper reviews recent findings on the efficacy of psychopharmacological interventions in autism, points out gaps in knowledge of the effects of specific drug classes, and suggests research directions for the future. (Author/DB)

The article reviews various therapies for hyperactivity including pharmacological and behavioral therapies. The heterogeneous nature of this population suggests that punishment procedures used as part of a behavioral management intervention may be effective in establishing responsible behavior and warrant more research. (Author/DB)

Use of the psychostimulant methylphenidate (MPH) to treat selected symptoms of autistic disorder was evaluated with 10 children, ages 7 to 11. The double-blind crossover study using a placebo and two MPH doses found modest but statistically significant improvement on hyperactivity in subjects receiving the MPH rather than the placebo. No…

This paper reports on a six-month continuation treatment with naltrexone of six children with autism, previously found to be responsive to naltrexone in a four-week trial. Results indicated the moderate hyperactivity-reducing effect of naltrexone was maintained during the six-month continuation treatment but no additional gains in the domains of…

Psychotropic drug-prescribing patterns for 474 adults with mental retardation residing at an intermediate-care facility were examined for a 10-year period. Results indicated a progressive, marked decrease in total psychotropic drug usage and changes in the type of drugs prescribed with overall decline in drug usage. (Author/DB)