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Safety and Efficacy of ABT-089 in Pediatric Attention-Deficit/Hyperactivity Disorder: Results from Two Randomized Placebo-Controlled Clinical Trials
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Wilens, Timothy E.; Gault, Laura M.; Childress, Ann; Kratochvil, Christopher J.; Bensman, Lindsey; Hall, Coleen M.; Olson, Evelyn; Robieson, Weining Z.; Garimella, Tushar S.; Abi-Saab, Walid M.; Apostol, George; Saltarelli, Mario D. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: To assess the safety and efficacy of ABT-089, a novel alpha[subscript 4]beta[subscript 2] neuronal nicotinic receptor partial agonist, vs. placebo in children with attention-deficit/hyperactivity disorder (ADHD). Method: Two multicenter, randomized, double-blind, placebo-controlled, parallel-group studies of children 6 through 12 years…
Descriptors: Attention Deficit Hyperactivity Disorder, Physical Examinations, Safety, Rating Scales
Review of ADHD Pharmacotherapies: Advantages, Disadvantages, and Clinical Pearls
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Daughton, Joan M.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The advantages, disadvantages, as well as helpful hints on when to use several drug therapies against attention deficit hyperactivity disorder are discussed. The drugs discussed are methylphenidate, atomoxetine, clonidine, and bupropion.
Descriptors: Attention Deficit Hyperactivity Disorder, Drug Therapy, Outcomes of Treatment, Pharmacology
Remission and Recovery in the Treatment for Adolescents with Depression Study (TADS): Acute and Long-Term Outcomes
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Kennard, Betsy D.; Silva, Susan G.; Tonev, Simon; Rohde, Paul; Hughes, Jennifer L.; Vitiello, Benedetto; Kratochvil, Christopher J.; Curry, John F.; Emslie, Graham J.; Reinecke, Mark; March, John – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The remission and recovery rates of adolescent patients with depression who were treated with fluoxetine, cognitive-behavioral therapy, their combination, and placebos were examined through a multisite clinical trial. It is concluded that most depressed adolescents who received such therapies achieved remission at the end of nine months.
Descriptors: Outcomes of Treatment, Adolescents, Patients, Therapy
Relative Cost-Effectiveness of Treatments for Adolescent Depression: 36-Week Results from the TADS Randomized Trial
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Domino, Marisa Elena; Foster, E. Michael; Vitiello, Benedetto; Kratochvil, Christopher J.; Burns, Barbara J.; Silva, Susan G.; Reinecke, Mark A.; March, John S. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Randomized controlled trials that involve 327 participants aged 12 to 18 who were diagnosed with major depression were given either fluoxetine alone, cognitive-behavioral therapy, or a combination of both. Cost-effectiveness acceptability curves suggest that combination treatment is highly likely to be the most cost-effective treatment than…
Descriptors: Cost Effectiveness, Depression (Psychology), Adolescents, Control Groups
Recent NIMH Clinical Trials and Implications for Practice
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Vitiello, Benedetto; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
Optimal treatment of adolescent depression requires the use of antidepressants such as fluoxetine, and the addition of cognitive-behavioral therapy (CBT) offers better potential. Second-step pharmacological treatment of the disorder offers a success rate of around 50%. Clinical trial for the use of sertraline and CBT in treating…
Descriptors: Depression (Psychology), Adolescents, Children, Drug Therapy
An Exploratory Analysis of the Impact of Family Functioning on Treatment for Depression in Adolescents
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Feeny, Norah C.; Silva, Susan G.; Reinecke, Mark A.; McNulty, Steven; Findling, Robert L.; Rohde, Paul; Curry, John F.; Ginsburg, Golda S.; Kratochvil, Christopher J.; Pathak, Sanjeev M.; May, Diane E.; Kennard, Betsy D.; Simons, Anne D.; Wells, Karen C.; Robins, Michele; Rosenberg, David; March, John S. – Journal of Clinical Child and Adolescent Psychology, 2009
This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of…
Descriptors: Conflict, Cognitive Restructuring, Adolescents, Family Environment
High-Dose Atomoxetine Treatment of ADHD in Youths with Limited Response to Standard Doses
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Kratochvil, Christopher J.; Michelson, David; Newcorn, Jeffrey H.; Weiss, Margaret D.; Busner, Joan; Moore, Rodney J.; Ruff, Dustin D.; Ramsey, Janet; Dickson, Ruth; Turgay, Atilla; Saylor, Keith E.; Luber, Stephen; Vaughan, Brigette; Allen, Albert J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To assess the utility and tolerability of higher than standard atomoxetine doses to treat attention-deficit/hyperactivity disorder (ADHD). Method: Two randomized, double-blind trials of atomoxetine nonresponders ages 6 to 16 years were conducted comparing continued treatment with same-dose atomoxetine to treatment using greater than…
Descriptors: Hyperactivity, Attention Deficit Disorders, Rating Scales, Patients
Emotional Expression in Children Treated with ADHD Medication: Development of a New Measure
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Perwien, Amy R.; Kratochvil, Christopher J.; Faries, Douglas; Vaughan, Brigette; Busner, Joan; Saylor, Keith E.; Buermeyer, Curtis M.; Kaplan, Stuart; Swindle, Ralph – Journal of Attention Disorders, 2008
Objective: Although existing instruments contain items addressing the effect of ADHD medications on emotional expression, a review of measures did not yield any instruments that thoroughly evaluated positive and negative aspects of emotional expression. Method: The Expression and Emotion Scale for Children (EESC), a parent-report measure, was…
Descriptors: Focus Groups, Factor Analysis, Psychometrics, Emotional Response
Is There a Role for Clozapine in the Treatment of Children and Adolescents?
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Findling, Robert L.; Frazier, Jean A.; Gerbino-Rosen, Ginny; Kranzler, Harvey N.; Kumra, Sanjiv; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
This article presents responses to the question of whether clozapine is ever appropriate to use in the pediatric population. Among others, Jean A. Frazier also agreed that clozapine is appropriate for use in the pediatric population. Clozapine has truly revolutionized the treatment of refractory patients with schizophrenia at any age. This agent…
Descriptors: Patients, Adolescents, Schizophrenia, Pediatrics
Pharmacological Management of Bipolar Disorder in a Youth with Diabetes
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DelBello, Melissa P.; Correll, Christoph U.; Carlson, Gabrielle A.; Carlson, Harold E.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
In this article, four clinicians respond to the following case vignette: A 12-year-old girl with insulin-dependent diabetes presents for treatment of her newly diagnosed bipolar disorder. How would you address the bipolar disorder pharmacologically, and how would the presence of diabetes affect your selection of medication and clinical management?
Descriptors: Mental Disorders, Diabetes, Depression (Psychology), Drug Therapy
Dysfunctional Attitudes Scale Perfectionism: A Predictor and Partial Mediator of Acute Treatment Outcome among Clinically Depressed Adolescents
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Jacobs, Rachel H.; Silva, Susan G.; Reinecke, Mark A.; Curry, John F.; Ginsburg, Golda S.; Kratochvil, Christopher J.; March, John S. – Journal of Clinical Child and Adolescent Psychology, 2009
The effect of perfectionism on acute treatment outcomes was explored in a randomized controlled trial of 439 clinically depressed adolescents (12-17 years of age) enrolled in the Treatment for Adolescents with Depression Study (TADS) who received cognitive behavior therapy (CBT), fluoxetine, a combination of CBT and FLX, or pill placebo. Measures…
Descriptors: Outcomes of Treatment, Behavior Modification, Suicide, Rating Scales
Research Knowledge among the Participants in the Treatment for Adolescents with Depression Study (TADS)
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Vitiello, Benedetto; Kratochvil, Christopher J.; Silva, Susan; Curry, John; Reinecke, Mark; Pathak, Sanjeev; Waslick, Bruce; Hughes, Carroll W.; Prentice, Ernest D.; May, Diane E.; March, John S. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
A study examined the extent to which parents and adolescents participating in the Treatment for Adolescents With Depression Study (TADS) understood the study. The results concluded that most were well-informed, and also parents were overall better informed than adolescents.
Descriptors: Adolescents, Depression (Psychology), Comprehension, Evaluation Research
Antidepressant Management in the Context of Suicidal Ideation
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Emslie, Graham J.; Waslick, Bruce; Weller, Elizabeth B.; Kloos, Angelica; Weller, Ronald A.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
A 15-year-old male presents with moderately severe depression, and fluoxetine 20 mg is initiated. When he returns 14 days later, he describes suicidal ideations for the first time. He has recurrent thoughts of wishing he were dead, a plan, but no intent to act. How would this affect medication management? This article presents the opinions of five…
Descriptors: Suicide, Depression (Psychology), Males, Adolescents
Selecting an Antidepressant for the Treatment of Pediatric Depression
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Kratochvil, Christopher J.; Vitiello, Benedetto; Brent, David; Bostic, Jeff Q.; Naylor, Michael W. – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
This column aims to discuss practical approaches to everyday issues in pediatric pharmacotherapy. The cases and discussions specifically target aspects of clinical care related to psychopharmacology for which there are no adequate applicable controlled trials. Given the need to address symptoms in youths with complex, severe, and comorbid…
Descriptors: Pharmacology, Cognitive Processes, Pediatrics, Depression (Psychology)
Pharmacological Management of Agitation and Aggression in an Adolescent with Autism
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Kratochvil, Christopher J.; Findling, Robert L.; McDougle, Christopher J.; Scahill, Lawrence; Hamarman, Stephanie – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
This article provides an "autism vignette" and then poses an evaluative question to several autism specialists, documenting their varied responses to the scenario and question posed. A 13-year-old boy with autism and severe mental retardation presented to the inpatient psychiatric unit due to a recent increase in agitation and physical aggression.…
Descriptors: Severe Mental Retardation, Drug Therapy, Autism, Aggression
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