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Direct linkLomas Mevers, Joanna; Call, Nathan A.; Gerencser, Kristina R.; Scheithauer, Mindy; Miller, Sarah J.; Muething, Colin; Hewett, Shannon; McCracken, Courtney; Scahill, Lawrence; McElhanon, Barbara O. – Journal of Autism and Developmental Disorders, 2020
Children with autism spectrum disorder (ASD) are often delayed in achieving bowel continence, resulting in negative outcomes. In this pilot trial, 20 children with ASD and encopresis were randomly assigned to multidisciplinary intervention for encopresis (MIE; n = 10) or a waitlist control group (n = 10). The MIE group was treated for constipation…
Descriptors: Autism, Pervasive Developmental Disorders, Behavior Modification, Intervention
Scahill, Lawrence; Sukhodolsky, Denis G.; Anderberg, Emily; Dimitropoulos, Anastasia; Dziura, James; Aman, Michael G.; McCracken, James; Tierney, Elaine; Hallett, Victoria; Katz, Karol; Vitiello, Benedetto; McDougle, Christopher – Autism: The International Journal of Research and Practice, 2016
Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism…
Descriptors: Autism, Pervasive Developmental Disorders, Scores, Networks
Erickson, Craig A.; Veenstra-Vanderweele, Jeremy M.; Melmed, Raun D.; McCracken, James T.; Ginsberg, Lawrence D.; Sikich, Linmarie; Scahill, Lawrence; Cherubini, Maryann; Zarevics, Peter; Walton-Bowen, Karen; Carpenter, Randall L.; Bear, Mark F.; Wang, Paul P.; King, Bryan H. – Journal of Autism and Developmental Disorders, 2014
STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown preliminary evidence of benefit in fragile X syndrome. We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32…
Descriptors: Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Drug Therapy
Scahill, Lawrence; McCracken, James T.; Bearss, Karen; Robinson, Fay; Hollander, Eric; King, Bryan; Bregman, Joel; Sikich, Lin; Dukes, Kimberly; Sullivan, Lisa; Anagnostou, Evdokia; Donnelly, Craig; Kim, Young-Shin; Ritz, Louise; Hirtz, Deborah; Wagner, Ann – Journal of Autism and Developmental Disorders, 2012
The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9.3 (plus or minus 3.12) years; 132 (88.6%) were…
Descriptors: Pharmacology, Drug Therapy, Pervasive Developmental Disorders, Autism
Arnold, L. Eugene; Aman, Michael G.; Li, Xiaobai; Butter, Eric; Humphries, Kristina; Scahill, Lawrence; Lecavalier, Luc; McDougle, Christopher J.; Swiezy, Naomi B.; Handen, Benjamin; Wilson, Krystina; Stigler, Kimberly A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: To follow up on a three-site, 24-week randomized clinical trial (N = 124) comparing antipsychotic medication alone (MED) with antipsychotic medication plus parent training in the behavior management (COMB) of children with autism spectrum disorders and severe behavior problems. The COMB treatment had shown a significant advantage for…
Descriptors: Behavior Disorders, Familiarity, Parents, Hyperactivity
Farmer, Cristan; Lecavalier, Luc; Yu, Sunkyung; Arnold, L. Eugene; McDougle, Christopher J.; Scahill, Lawrence; Handen, Benjamin; Johnson, Cynthia R.; Stigler, Kimberly A.; Bearss, Karen; Swiezy, Naomi B.; Aman, Michael G. – Journal of Autism and Developmental Disorders, 2012
The Research Units on Pediatric Psychopharmacology-Autism Network reported additional benefit when adding parent training (PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat analyses were rerun with putative predictors and moderators. The "Home Situations…
Descriptors: Behavior Problems, Autism, Hyperactivity, Predictor Variables
Scahill, Lawrence; McDougle, Christopher J.; Aman, Michael G.; Johnson, Cynthia; Handen, Benjamin; Bearss, Karen; Dziura, James; Butter, Eric; Swiezy, Naomi G.; Arnold, L. Eugene; Stigler, Kimberly A.; Sukhodolsky, Denis D.; Lecavalier, Luc; Pozdol, Stacie L.; Nikolov, Roumen; Hollway, Jill A.; Korzekwa, Patricia; Gavaletz, Allison; Kohn, Arlene E.; Koenig, Kathleen; Grinnon, Stacie; Mulick, James A.; Yu, Sunkyung; Vitiello, Benedetto – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: Children with Pervasive Developmental Disorders (PDDs) have social interaction deficits, delayed communication, and repetitive behaviors as well as impairments in adaptive functioning. Many children actually show a decline in adaptive skills compared with age mates over time. Method: This 24-week, three-site, controlled clinical trial…
Descriptors: Socialization, Autism, Interpersonal Relationship, Interaction
Olfson, Mark; Crystal, Stephen; Gerhard, Tobias; Huang, Cecilia; Walkup, James T.; Scahill, Lawrence; Walkup, John T. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: This study examined the prevalence and demographic and clinical correlates of children diagnosed with Tourette disorder, chronic motor or vocal tic disorder, and other tic disorders in public and private insurance plans over the course of a 1-year period. Method: Claims were reviewed of Medicaid (n = 10,247,827) and privately (n =…
Descriptors: Attention Deficit Hyperactivity Disorder, Health Services, Mental Disorders, Identification
Jahromi, Laudan B.; Kasari, Connie L.; McCracken, James T.; Lee, Lisa S-Y.; Aman, Michael G.; McDougle, Christopher J.; Scahill, Lawrence; Tierney, Elaine; Arnold, L. Eugene; Vitiello, Benedetto; Ritz, Louise; Witwer, Andrea; Kustan, Erin; Ghuman, Jaswinder; Posey, David J. – Journal of Autism and Developmental Disorders, 2009
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of…
Descriptors: Pervasive Developmental Disorders, Hyperactivity, Self Control, Interpersonal Communication
Scahill, Lawrence; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Handen, Benjamin; Johnson, Cynthia; Dziura, James; Butter, Eric; Sukhodolsky, Denis; Swiezy, Naomi; Mulick, James; Stigler, Kimberly; Bearss, Karen; Ritz, Louise; Wagner, Ann; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2009
This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes…
Descriptors: Intervention, Pervasive Developmental Disorders, Parent Education, Drug Therapy
Peer reviewedGreenhill, Laurence L.; Vitiello, Benedetto; Fisher, Prudence; Levine, Jerome; Davies, Mark; Abikoff, Howard; Chrisman, Allan K.; Chuang, Shirley; Findling, Robert L.; March, John; Scahill, Lawrence; Walkup, John; Riddle, Mark A. – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To improve the gathering of adverse events (AEs) in pediatric psychopharmacology by examining the value and acceptability of increasingly detailed elicitation methods. Method: Trained clinicians administered the Safety Monitoring Uniform Report Form (SMURF) to 59 parents and outpatients (mean age [+ or -] SD = 11.9 [+ or -] 3.2 years)…
Descriptors: Safety, Psychiatry, Pharmacology, Pediatrics
Peer reviewedVitiello, Benedetto; Aman, Michael G.; Scahill, Lawrence; McCracken, James T.; McDougle, Christopher J.; Tierney, Elaine; Davies, Mark; Arnold, L. Eugene – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: Parental permission is required for child research, but parents' understanding of research aims and procedures has not been well documented. Parental research knowledge was assessed during a clinical trial in autism. Method: Parents of 101 children (age 5-17 years) with autism participating in a placebo-controlled trial of risperidone…
Descriptors: Measures (Individuals), Psychiatry, Ethics, Autism
Peer reviewedKratochvil, Christopher J.; Findling, Robert L.; McDougle, Christopher J.; Scahill, Lawrence; Hamarman, Stephanie – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
This article provides an "autism vignette" and then poses an evaluative question to several autism specialists, documenting their varied responses to the scenario and question posed. A 13-year-old boy with autism and severe mental retardation presented to the inpatient psychiatric unit due to a recent increase in agitation and physical aggression.…
Descriptors: Severe Mental Retardation, Drug Therapy, Autism, Aggression
Lindsay, Ronald L.; Arnold, L. Eugene; Aman, Michael G.; Vitiello, Benedetto; Posey, David J.; McDougle, Christopher J.; Scahill, Lawrence; Pachler, Maryellen; McCracken, James T.; Tierney, Elaine; Bozzolo, Dawn – Journal of Intellectual and Developmental Disability, 2006
Background: Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain. Method: Using a quantitative Food Frequency Questionnaire (FFQ), we prospectively examined the nutritional intake of 20 children with autism participating in a randomised…
Descriptors: Autism, Nutrition, Behavior Disorders, Children
Peer reviewedMartin, Andres; Koenig, Kathleen; Anderson, George M.; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2003
This prospective open-label study assessed the efficacy and tolerability of low-doze fluvoxamine in 14 children with pervasive developmental disorders (PDDs). Although there was no response for the group as a whole, eight subjects were considered at least partial responders in intent-to-treat analyses. Results suggest fluvoxamine can be beneficial…
Descriptors: Adolescents, Children, Drug Therapy, Elementary Secondary Education
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