Centers for teaching and learning (CTLs) exist in dynamic contexts and need to be agile, with skilled, adaptable teams to prepare for and respond to changes. In this article, we provide CTL leaders with relevant and eminently practical strategies from the human resources (HR) literature, offering guidance in the four areas of organizational structure, direction-setting, capacity-building, and accountability. For each area, we address pivotal challenges with practical approaches grounded in existing research and theory to provide options for CTL leaders in their quest to have well-functioning, agile units. Examples focus on helping existing centers to adapt and refocus, as needed, in response to evolving contexts and priorities.