The great advantages of e-learning have been recognized, and efforts have been made to promote e-learning adoption. Despite valuable research achievements from technology adoption, previous studies built their models from different perspectives. In this study, to offer a comprehensive research model on e-learning adoption, we integrated these models (ie, TAM, TPB and IDT) and included culture as a moderator. Based on 45 relevant empirical research, this study conducted a meta-analysis to explore key determinants of users' attitude and behavioral intention to adopt e-learning. Combined with traditional technology acceptance theories and innovation diffusion theory, we developed a comprehensive model and explored the moderating role of culture. The results indicate that this integrated technology acceptance model can be applied to better understand e-learning adoption. The moderator analysis shows that the influence of subjective norms and self-efficacy on users' behavior intention is more salient in the collectivistic culture, whereas perceived usefulness is more important for online learners in an individualistic culture.