This brief seeks to serve as a clarion call for all educators and policymakers who believe higher education is a viable pathway to socioeconomic prosperity and eradicating centuries of generational poverty for Black people residing in the U.S. Despite the enactment of the Civil Rights Act of 1964, which marked the end of de jure segregation in the U.S., Black people continue to suffer the consequences of slavery, Jim Crow segregation, and anti-Black racism, as expressed in unequal access to a quality education and job opportunities across the U.S. In this brief, the authors discuss the current status of Black students in higher education, with a particular focus on recent trends in college enrollment, persistence, and attainment. The authors highlight salient challenges and issues that impact the ways in which Black students experience college and university campuses. They discuss the challenges that Black students must often navigate to focus on opportunities that can be leveraged to improve both their experiences and outcomes in higher education. In doing so, the authors propose a set of innovations and promising practices that can be enacted by college and university leaders. Finally, they offer policy solutions for higher education leaders and state and federal policymakers that can eliminate systemic barriers and transform higher education to ensure Black student success. [Additional funding provided by Eileen and Harold Brown.]