While issues faced by Catholic schools around the world depend on local context, a number of common challenges are often encountered globally. This article considers eight such challenges: (1) the decline in the depth of faith and values; (2) an inadequate number of clergy and religious serving in schools; (3) a changing scenario for teaching personnel; (4) a changing face of families; (5) ethical and religious pluralism; (6) inadequate child safety mechanism; (7) lack of research, data and documentation; and finally (8) the need for catholic Schools to reach the socio-economically marginalized. Based on an analysis of these challenges, the article suggests step that Catholic schools can take to meet those challenges. The article is adapted with minor modifications from an address at the opening session of the OIEC World Congress held in New York in June 2019.