Psychostimulant exposure has been shown to cause molecular and cellular changes in prefrontal cortex. It has been hypothesized that these drug-induced changes might affect the operation of prefrontal-limbic circuits, disrupting their normal role in controlling behavior and thereby leading to compulsive drug-seeking. To test this hypothesis, we…

Previous studies showed that the serum- and glucocorticoid-inducible kinase ("sgk") gene plays an important role in long-term memory formation. The present study further examined the role of SGK in long-term potentiation (LTP). The dominant-negative mutant of "sgk," SGKS422A, was used to inactivate SGK. Results revealed a time-dependent increase…

Research suggests that intuitive parental didactics related to infants' production of vocal sounds, vocal imitation, and vocal play are a prerequisite of human language acquisition. Microanalyses of videorecords of parent-infant interactions have revealed intuitive forms of parental behaviors that parents carry out unknowingly and can hardly…

Permanent lesions in the medial prefrontal cortex (mPFC) affect acquisition of conditioned responses (CRs) during trace eyeblink conditioning and retention of remotely acquired CRs. To clarify further roles of the mPFC in this type of learning, we investigated the participation of the mPFC in mnemonic processes both during and after daily…

Maintains that the "getting into shape" hypothesis of explaining the inverted-U distribution of exercise play across age is likely incorrect. Argues that the biological study of human physical activity play, as recommended by Pellegrini and Smith (1998), will reveal whether physical activity play represents an example of…

The question of human origin has always been disputed by evolution theorists. This book provides a comprehensive survey of the debates over human evolution from the time of Darwin to the 1940s. Part 1 discusses the early controversies, noting that they focused on philosophical issues rather than causes or details of the evolutionary process. A…

This paper argues that the emerging discipline of sociobiology has the potential of doing what epistemologists, developmental psychologists, psychoanalysts, and ethologists have been unable to do: to provide a theory documenting our inherited dispositions as reflected in cultural evolution and personal development. Accordingly, the paper begins…