The partial correlation coefficient (PCC) is used to quantify the linear relationship between two variables while taking into account/controlling for other variables. Researchers frequently synthesize PCCs in a meta-analysis, but two of the assumptions of the common equal-effect and random-effects meta-analysis model are by definition violated.…

When meta-analyzing heterogeneous bodies of literature, meta-regression can be used to account for potentially relevant between-studies differences. A key challenge is that the number of candidate moderators is often high relative to the number of studies. This introduces risks of overfitting, spurious results, and model non-convergence. To…

During drug development, a biomarker is sometimes identified as separating a patient population into those with more and those with less benefit from evaluated treatments. Consequently, later studies might be targeted, while earlier ones are performed in mixed patient populations. This poses a challenge in evidence synthesis, especially if only…

In meta-analytic studies, there are often multiple moderators available (eg, study characteristics). In such cases, traditional meta-analysis methods often lack sufficient power to investigate interaction effects between moderators, especially high-order interactions. To overcome this problem, meta-CART was proposed: an approach that applies…