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Direct linkMiriam Hattle; Joie Ensor; Katie Scandrett; Marienke van Middelkoop; Danielle A. van der Windt; Melanie A. Holden; Richard D. Riley – Research Synthesis Methods, 2024
Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment effect and participant-level…
Descriptors: Meta Analysis, Randomized Controlled Trials, Outcomes of Treatment, Evaluation Methods
Proctor, Tanja; Zimmermann, Samuel; Seide, Svenja; Kieser, Meinhard – Research Synthesis Methods, 2022
During drug development, a biomarker is sometimes identified as separating a patient population into those with more and those with less benefit from evaluated treatments. Consequently, later studies might be targeted, while earlier ones are performed in mixed patient populations. This poses a challenge in evidence synthesis, especially if only…
Descriptors: Comparative Analysis, Meta Analysis, Patients, Medical Research
Piepho, Hans-Peter; Madden, Laurence V. – Research Synthesis Methods, 2022
Network meta-analysis is a popular method to synthesize the information obtained in a systematic review of studies (e.g., randomized clinical trials) involving subsets of multiple treatments of interest. The dominant method of analysis employs within-study information on treatment contrasts and integrates this over a network of studies. One…
Descriptors: Medical Research, Meta Analysis, Networks, Drug Therapy
Download full textDemack, Sean; Maxwell, Bronwen; Coldwell, Mike; Stevens, Anna; Wolstenholme, Claire; Reaney-Wood, Sarah; Stiell, Bernadette; Lortie-Forgues, Hugues – Education Endowment Foundation, 2021
This report presents findings from exploratory, descriptive meta-analyses of effect sizes reported by the first 82 EEF evaluations that used a randomised controlled trial (RCT) or clustered RCT impact evaluation design published up to January 2019. The review used a theoretical framework derived from literature with five overarching themes to…
Descriptors: Foreign Countries, Disadvantaged Youth, Meta Analysis, Effect Size
Demack, Sean; Maxwell, Bronwen; Coldwell, Mike; Stevens, Anna; Wolstenholme, Claire; Reaney-Wood, Sarah; Stiell, Bernadette; Lortie-Forgues, Hugues – Education Endowment Foundation, 2021
This document summarises key findings from the quantitative strands of a review of the Education Endowment Foundation (EEF) evaluations that had reported from the establishment of EEF in 2011 up to January 2019. The quantitative strands summarised include meta-analyses of effect sizes reported for attainment outcomes and descriptive analyses of…
Descriptors: Foreign Countries, Disadvantaged Youth, Meta Analysis, Effect Size
Demack, Sean; Maxwell, Bronwen; Coldwell, Mike; Stevens, Anna; Wolstenholme, Claire; Reaney-Wood, Sarah; Stiell, Bernadette; Lortie-Forgues, Hugues – Education Endowment Foundation, 2021
This document provides supplementary statistical tables to support the review of Education Endowment Foundation (EEF) evaluations. This includes: (1) Descriptive (univariate) tables for all explanatory variables; (2) Tables for the meta-analyses of primary ITT effect sizes; (3) Tables for the meta-analyses of secondary ITT effect sizes; (4) Tables…
Descriptors: Foreign Countries, Disadvantaged Youth, Meta Analysis, Effect Size
