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Direct linkHuiskens, Joost; Kool, Boudewijn R. J.; Bakker, Jean-Michel; Bruns, Emma R. J.; de Jonge, Stijn W.; Olthof, Pim B.; van Rosmalen, Belle V.; van Gulik, Thomas M.; Hooft, Lotty; Punt, Cornelis J. A. – Research Synthesis Methods, 2020
Introduction: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination of results, and the prevalence of consistency in hypothesis, sample size, and primary endpoint of Dutch…
Descriptors: Randomized Controlled Trials, Databases, Foreign Countries, Medical Research
Holmes, Eileen M.; Leahy, Joy; Walsh, Cathal D.; White, Arthur; Donnan, Peter T.; Lamrock, Felicity – Research Synthesis Methods, 2019
Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe…
Descriptors: Decision Making, Drug Therapy, Comparative Analysis, Pharmacology
