Objectives: To examine differences in compliance to follow-up for STD based on demographic, clinical and academic characteristics. Methods: Cross-sectional study examining associations between clinical, demographic and academic variables and compliance to follow-up for STDs in a college population. Participants: Chart review data collected at University Health Services (UHS) UW- Madison, where 449 cases were reported in 2017. Results: Final model includes sex, sex of partners and its interaction. It shows no significant difference in follow-up for males compared to females or for students having partners of the same sex nor students having partners of the same and different sex. Finally, when interactions are introduced, males having partners of a different sex were significantly associated with less compliant follow-up (AOR: 10.36; 95% CI= 1.57- 68.35). Conclusions: The effect of the sexual partners in noncompliance differs by sex. Males with partners of a different sex were 10 times more likely to noncompliance to follow up than females with partners of a different sex.