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Trisomy 16 in a Pigtailed Macaque ("M. nemestrina") with Multiple Anomalies and Developmental Delays
Peer reviewed
Direct linkRuppenthal, Gerald C.; Moore, Charleen M.; Best, Robert G.; Walker-Gelatt, Coleen G.; Delio, Patrick J.; Sackett, Gene P. – American Journal on Mental Retardation, 2004
A female pigtailed macaque ("Macaca nemestrina") with unusual physical characteristics, deficits in learning and cognitive tasks, abnormal social behavior, and abnormal reflexes and motor control was followed from birth until 3 years of age and found to have trisomy 16, which is homologous to trisomy 13 in humans. The animal described here showed…
Descriptors: Primatology, Physical Characteristics, Social Behavior, Genetics
Verbitsky, Miguel; Yonan, Amanda L.; Malleret, Gael; Kandel, Eric R.; Gilliam, T. Conrad; Pavlidis, Paul – Learning & Memory, 2004
We have carried out a global survey of age-related changes in mRNA levels in the 57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged…
Descriptors: Profiles, Animals, Memory, Brain Hemisphere Functions
Welham, Nathan V.; Marriott, Gerard; Bless, Diane M. – Journal of Speech, Language, and Hearing Research, 2006
Purpose: Proteomic methodologies offer promise in elucidating the systemwide cellular and molecular processes that characterize normal and diseased thyroarytenoid (TA) muscle. This study examined methodological issues central to the application of 2-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D SDS-PAGE) to the study of…
Descriptors: Animals, Anatomy, Evaluation Methods, Cytology
