This study aims to investigate the effectiveness of the application of mathematical software to the mathematical abilities of students in Indonesia. For this purpose, 64 effect sizes from 51 studies published in national and international journals from 2011 to 2019 were analyzed using the meta-analysis method. Comprehensive Meta-Analysis (CMA) software is used to assist the analysis. Hedges's g coefficient was used when the effect sizes were calculated and the confidence level was accepted as 95%. As a result of the study, the overall effect size was 1.162, with a standard error of 0.091 according to the random-effects model. These results indicate that the average student who is ranked 13th in the experimental group is equivalent to those who are ranked 4th in the control group. The study was conducted by considering four characteristics, producing a significant difference in terms of the year when the study was conducted and the type of software used. Thus the use of mathematical software produces a larger effect on mathematical ability than conventional approaches.