The purpose of this study is to analyze and synthesize the recent research related to nationwide MOOC initiatives in Malaysian higher education that have been published from 2014 to 2018 in order to gain an overview of the growth of MOOC in Malaysia and to identify the issues facing implementation of nationwide MOOC initiatives in the Malaysian higher education context. This study utilized a descriptive systematic literature review (SLR) approach using systematic content analysis techniques to compile and analyze publications related to nationwide MOOC initiatives in the Malaysian higher education system. The 25 MOOC studies reviewed are categorized into three sections: Malaysia MOOC, followed by a summary of researches relevant to Malaysia MOOC and finally, issues of the nationwide MOOC implementation in Malaysia. Several recommendations are provided to expand MOOC's nationwide initiative in Malaysian higher education systems. The significance of the paper is twofold: (a) to inform researchers, designers, and teachers, about the state of the art of nationwide MOOC initiative in Malaysia; (b) to provide suggestions for adapting the nationwide MOOC initiative in Malaysian higher education system and other countries sharing similar interests in institutionalizing their MOOC.