The Learning Management System (LMS) facilitates the learning and teaching process in higher learning institutions (HLIs) using the Internet. Despite the advantage of having these LMS in institutions, usage is still a challenging problem. This study investigated the factors influencing the usage of LMS in HLIs. To achieve the objective of the study, the constructs were adopted from TAM, UTAUT2, and the D&M success models. Data were collected using questionnaires followed by interviews with key people at the University of Dodoma (UDOM). A mixed-method sequential explanatory design was used to analyze the data collected from 92 participants. The results revealed that perceived usefulness, instructors' self-efficacy, and intrinsic motivation have an influence on the usage of LMS amongst instructors in HLIs. The findings of this study will help the HLIs and LMS implementers to find the strategies that will assist them in increasing LMS usage to achieve desired results.