Background: While many settler allies are eager to help towards the goal of disrupting racism, a clearer understanding of how best to harness this eagerness is required within the field of Indigenous health, a field currently comprised mainly non-Indigenous scholars, researchers and educators. Purpose: Responding to this challenge, this article aims to identify ways of working towards disrupting settler colonialism and addressing racism in all of its manifestations by building settler allyship and adopting an anti-racist lens within the field of Indigenous health. The article describes how to approach building settler allyship by implementing anti-racist acts. Method: By using anti-racist scholarship and showcasing recent public examples of anti-Indigenous racism, the author describes how settler allies can approach developing unsettled, critical and anti-racist conversations with one another and in respectful ways with Indigenous peoples. As many Indigenous peoples continue to identify ongoing racism, there is a need for informed, unsettled, anti-racist allies willing to challenge their own complicity to then take action when anti-Indigenous racism occurs. Actions include critical self-reflection, confronting white supremacy and implementing demonstrably anti-racist acts. Conclusion: Findings provide the basis for amplifying unsettling conversations between engaged settler allies to develop anti-racist ways of fostering and extending relationships with Indigenous people and scholars.