The complete structural analysis and resynthesis of an unknown compound, selected from a library of dipeptides, provided a framework for a course that built from expository experiments toward a guided-inquiry approach. We used this semester-long lab as a replacement for conventional second semester organic chemistry laboratory and successfully…

A multioutcome, guided inquiry-based liquid--liquid extraction (LLE) experiment has been designed for introductory organic chemistry. Multiple outcomes were established by identifying a series of red and blue dyes that are (1) soluble in organic solvent, (2) soluble in aqueous solution, or (3) soluble in either the organic or aqueous layers by…

An undergraduate experiment for the organic laboratory is described that utilizes microwave heating to prepare 5- substituted 1H-tetrazole derivatives through a (3 + 2) cycloaddition between aryl nitriles and sodium azide. The reaction mixture is analyzed by thin layer chromatography. The products are purified through an acid-base extraction and…

There is an increasing need for students in the biological sciences to build a strong foundation in quantitative approaches to data analyses. Although most science, engineering, and math field majors are required to take at least one statistics course, statistical analysis is poorly integrated into undergraduate biology course work, particularly…