Background: Online exercise programming reduces transportation and scheduling barriers. This study explored the feasibility of online resistance training for individuals with Down syndrome. Method: Thirteen individuals (3 M/10 F, age: 21.7 ± 5.9 years) began a 10-week programme delivered using a website with pre-recorded exercise videos (45--60 min each) for 3 days/week. Surveys were used to obtain feedback and track adherence. At baseline and after 10 weeks, participants completed the 30-s sit-to-stand, modified push-ups and 30-s bicep curl tests. Results: 11 (85%) participants completed the programme, and 8 participants (73%) met the = 20 sessions goal. Participants rated (n = 267 ratings) most exercises easy to somewhat easy and exercise videos as fun to a lot of fun (n = 220 ratings, 86.2%). After 10 weeks, participants completed more push-ups (8 ± 6 vs. 12 ± 6; p = 0.031) and biceps curls (7 ± 3 vs. 11 ± 3; p < 0.001). Conclusion: Remote resistance training programmes may be feasible and should be further evaluated.