Matrix metalloproteinases (MMPs) are a family of extracellularly acting proteolytic enzymes with well-recognized roles in plasticity and remodeling of synaptic circuits during brain development and following brain injury. However, it is now becoming increasingly apparent that MMPs also function in normal, nonpathological synaptic plasticity of the…

Discusses ways to devise training methods to improve students' learning abilities, specifically in rote recall, evaluation of the learning task, summarization, and learning from the text. (EF)

We explored the circumstances in which rats engage either declarative memory (and the hippocampus) or habit memory (and the dorsal striatum). Rats with damage to the hippocampus or dorsal striatum were given three different two-choice discrimination tasks (odor, object, and pattern). These tasks differed in the number of trials required for…

Recent research on early word learning suggests that children's behavior when-generalizing novel nouns integrates their prior vocabulary knowledge with the specifics of the task. This study examines how these factors interact on the moment-to-moment time scale of the training children receive and the sequence of stimuli they are shown. In 1…

The study investigated the dynamic relation between contingency learning and heart rate with risk and non-risk babies 5- to 10-months-old. Four groups were compared in a two contingency treatments (contingent, yoked) x two risk status design. Concurrent heart rate was monitored during three phases of a contingency learning task (baseline,…

The present study investigated the effects of acute stress exposure on learning performance in humans using analogs of two paradigms frequently used in animals. Healthy male participants were exposed to the cold pressor test (CPT) procedure, i.e., insertion of the dominant hand into ice water for 60 sec. Following the CPT or the control procedure,…

The transformation of episodic inputs to semantic representations was studied in two very similar tasks. In one, subjects were required to infer the underlying four-term linear ordering from three comparative sentences such as, "The teacher is taller than the doctor." In the second task, subjects inferred underlying 4- and 5-digit…

Examines problems of existing courseware authoring systems and suggests the use of knowledge-based techniques. A prototype knowledge-based representation language called GTE (Generic Tutoring Environment) is described that could form the basis of a full authoring environment, including generic tasks and instructional methods, domain knowledge, and…

The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training. To gain more insight into the involvement of CaN in these two types of learning, hippocampal CaN…

Extensive research has shown that the hippocampus is necessary for consolidation of long-term spatial memory in rodents. We reported previously that rats using a place strategy to solve a cross maze task showed sustained phosphorylation of hippocampus cyclic AMP response element-binding protein (CREB), a transcription factor implicated in…

Joint attention skills are an important part of human cultural learning. However, little is known about the emergence and meaning of these skills in early ontogeny. The development of, and relation among, various joint attention skills was assessed. Seventy-two 5 to 10-month-old infants were tested on a variety of joint attention tasks.…

Four experiments were conducted to investigate the relationship between the binding of visual features (as measured by their after-effects on subsequent binding) and the learning of feature-conjunction probabilities. Both binding and learning effects were obtained, but they did not interact. Interestingly, (shape-color) binding effects…

Cognitive performance is affected by an individual's characteristics and the environment, as well as by the nature of the task and the amount of practice at it. Mental performance tests range in complexity and include subjective estimates of mood, simple objective tests (reaction time), and measures of complex performance that require decisions to…

Semantic and orthographic learning of new words was investigated with the help of the picture-word interference (PWI) task. In this version of the Stroop task, picture naming is delayed by the simultaneous presentation of a semantically related as opposed to an unrelated distractor word (a specific PWI effect), as well as by an unrelated word…