In this paper, I address the question of how interactions with deaf youth and their hearing interlocutors are able to unfold in economical and fluid ways despite the existence of sensory and communicative asymmetries. Bringing together ethnographic insights from two years of fieldwork in Iquitos, Peru with the microanalysis of moments of situated interaction, I highlight the role that repetitions of similar assemblages of people, objects, and places play in the process of meaning-making between deaf youth and their hearing interlocutors. I argue that the repetition of similar assemblages facilitates the process of meaning-making by narrowing down the trajectory of the interactions that emerge in a particular moment and by providing the occasion for building shared semiotic resources specific to the reoccurring activity.