As research evidence for the facilitative effects of reading strategies on reading comprehension has been accumulating, research and pedagogical interests in prereading strategies such as prediction and schema[superscript activation] are increasing. Yet, little research evidence of how actual performance on such tasks may be related to reading comprehension is sparse. This study explores whether prediction abilities and content schema are related to Korean middle school EFL learners' reading comprehension abilities in English, and whether such potential relations may differ for factual and inferential comprehension. The study participants were one hundred thirty-seven Korean seventh grade students, and their performance on schema activation, prediction, and reading comprehension abilities was investigated, while controlling for their overall language proficiency and literacy skills. The findings indicated that although both prediction abilities and content schema facilitated reading comprehension, prediction abilities were a relatively stronger predictor of both factual and inferential comprehension. The results further suggest the need to provide effective trainings on pre-reading strategies.