Valid consent requires the potential research participant understands the information provided. We examined current practice in 50 proposed Clinical Trials of Investigational Medicinal Products to determine how this understanding is checked. The majority of the proposals (n = 44) indicated confirmation of understanding would take place during an…

Medical researchers are ethically and legally required to inform participants and get written permission before enrolling them into a human research project ("Informed Consent"). Accordingly, information and consent represent a complex procedure, and the participant concerned "must receive comprehensible oral and written…

This paper addresses psychological factors that might interfere with informed consent on the part of stable patients as potential early-phase clinical trial participants. Thirty-six semistructured interviews with patients who had either diabetes or gout were conducted. We investigated stable patients' attitudes towards participating in a…