Pathway-based differential expression analysis allows the incorporation of biological domain knowledge into transcriptomics analysis to enhance our understanding of disease mechanisms. To integrate information among multiple studies at the pathway level, pathway-based meta-analysis can be performed. Paired or partially paired samples are common in…

Since its release in late 2022, ChatGPT and subsequent generative artificial intelligence (GAI) tools have raised a wide variety of questions and concerns for the field of technical communication: How will these tools be incorporated into professional settings? How might we appropriately integrate these tools into our research and teaching? In…

Effect direction (evidence to indicate improvement, deterioration, or no change in an outcome) can be used as a standardized metric which enables the synthesis of diverse effect measures in systematic reviews. The effect direction (ED) plot was developed to support the synthesis and visualization of effect direction data. Methods for the ED plot…

Traditional visualization in meta-analysis uses forest plots to illustrate the combined treatment effect, along with the respective results from primary trials. While the purpose of visualization is clear in the pairwise setting, additional treatments broaden the focus and extend the results to be illustrated in network meta-analysis. The…

This paper addresses psychological factors that might interfere with informed consent on the part of stable patients as potential early-phase clinical trial participants. Thirty-six semistructured interviews with patients who had either diabetes or gout were conducted. We investigated stable patients' attitudes towards participating in a…

The Confidentiality Advisory Group (CAG) is a specialised body that advises the Health Research Authority (HRA) and the Secretary of State for Health on requests for access to confidential information, in the absence of informed consent from its owners. Its primary role is to oversee the safe use of such information and to counsel the governing…

This note outlines some connections between projective geometry and some designs used in clinical trials in the health sciences. The connections are not immediately obvious but they widen the scope for enrichment work at both the senior high school level and for capstone subjects at the undergraduate level.

The involvement of non-researcher contributors (eg, stakeholders, patients and the public, decision and policy makers, experts, lay contributors) has taken a variety of forms within evidence syntheses. Realist reviews are a form of evidence synthesis that involves non-researcher contributors yet this practice has received little attention. In…

The National Health Service (NHS) celebrated its 75th anniversary in 2023. Its founding principles of care for all, free at point of need, funded from general taxation, a source of British pride. However the public has growing concerns about the standard of care and is pessimistic about the future. The NHS Long Term Workforce Plan (LTWP),…

Although several entrepreneurship education programs (EEPs) have been created for faculty, research examining women faculty experiences participating in EEPs is minimal and particularly negligible in the context of their academic research. To address this gap, we examine women faculty's perceptions and experiences toward EEPs in the context of…

Mathematical modeling studies are increasingly recognised as an important tool for evidence synthesis and to inform clinical and public health decision-making, particularly when data from systematic reviews of primary studies do not adequately answer a research question. However, systematic reviewers and guideline developers may struggle with…

Lexical bundles (LBs) are frequent groups of words that appear repeatedly in different academic texts. A plethora of research has explored their distribution and usage in general, particularly in academic texts. However, to our knowledge, the extent of research investigating LBs in the discussion sections of Medical Research Articles (MRAs) is…

Mixed methods (MM) involve combining qualitative (QUAL) and quantitative (QUAN) methods in program evaluation, primary research, and literature reviews. MM are being increasingly used in health and social sciences (in multiple fields and in an inter-field manner). Over the years, several strategies to integrate QUAL and QUAN phases, results, and…

Introduction: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination of results, and the prevalence of consistency in hypothesis, sample size, and primary endpoint of Dutch…

Hofmann and Holm's (2019) recent survey on issues of research misconduct with PhD graduates culminated with a notable conclusion by the authors: 'Scientific misconduct seems to be an environmental issue as much as a matter of personal integrity'. Here, we re-emphasise the usefulness of an education-based countermeasure against toxic research…