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Direct linkJohnson, Sarah A.; Sacks, Patricia K.; Turner, Sean M.; Gaynor, Leslie S.; Ormerod, Brandi K.; Maurer, Andrew P.; Bizon, Jennifer L.; Burke, Sara N. – Learning & Memory, 2016
Hippocampal-dependent episodic memory and stimulus discrimination abilities are both compromised in the elderly. The reduced capacity to discriminate between similar stimuli likely contributes to multiple aspects of age-related cognitive impairment; however, the association of these behaviors within individuals has never been examined in an animal…
Descriptors: Brain Hemisphere Functions, Animals, Models, Tests
Knutson, Ashley R.; Hopkins, Ramona O.; Squire, Larry R. – Learning & Memory, 2013
We tested proposals that medial temporal lobe (MTL) structures support not just memory but certain kinds of visual perception as well. Patients with hippocampal lesions or larger MTL lesions attempted to identify the unique object among twin pairs of objects that had a high degree of feature overlap. Patients were markedly impaired under the more…
Descriptors: Visual Discrimination, Neurological Impairments, Patients, Memory
Yang, Mu; Lewis, Freeman C.; Sarvi, Michael S.; Foley, Gillian M.; Crawley, Jacqueline N. – Learning & Memory, 2015
Chromosomal 16p11.2 deletion syndrome frequently presents with intellectual disabilities, speech delays, and autism. Here we investigated the Dolmetsch line of 16p11.2 heterozygous (+/-) mice on a range of cognitive tasks with different neuroanatomical substrates. Robust novel object recognition deficits were replicated in two cohorts of 16p11.2…
Descriptors: Intellectual Disability, Delayed Speech, Autism, Genetics
Bartko, Susan J.; Winters, Boyer D.; Cowell, Rosemary A.; Saksida, Lisa M.; Bussey, Timothy J. – Learning & Memory, 2007
The perirhinal cortex (PRh) has a well-established role in object recognition memory. More recent studies suggest that PRh is also important for two-choice visual discrimination tasks. Specifically, it has been suggested that PRh contains conjunctive representations that help resolve feature ambiguity, which occurs when a task cannot easily be…
Descriptors: Visual Discrimination, Recognition (Psychology), Brain Hemisphere Functions, Memory
Squire, Larry R.; Levy, Daniel A.; Shrager, Yael – Learning & Memory, 2005
The perirhinal cortex is known to be important for memory, but there has recently been interest in the possibility that it might also be involved in visual perceptual functions. In four experiments, we assessed visual discrimination ability and visual discrimination learning in severely amnesic patients with large medial temporal lobe lesions that…
Descriptors: Visual Discrimination, Patients, Discrimination Learning, Memory
Peer reviewedMiranda, Simon B. – Merrill-Palmer Quarterly, 1976
Visual preference technique was found to be a method for exploring the genesis of normal and abnormal selective attention, pattern discrimination, and recognition memory. The study of infants with differing degrees of risk for mental subnormality produced substantial evidence for relationship between early visual selectivities and future…
Descriptors: Attention, Cognitive Development, Downs Syndrome, Drafting
