Background: Clinical trials of medications to alleviate the cognitive and behavioural symptoms of individuals with fragile X syndrome (FXS) are now underway. However, there are few reliable, valid and/or sensitive outcome measures available that can be directly administered to individuals with FXS. The majority of assessments employed in clinical…

The first gene-targeting studies that examined learning and memory in mice were performed in 1992 (Grant et al. 1992; Silva et al. 1992). The ultimate goal of this new field was to understand the molecular and cellular process underlying normal cognition and how they may be altered in disease states. In the years since these pioneering studies,…

The paper consists of a review of 24 studies on mental retardation published in two Soviet journals between 1970 and 1980. An introductory section focuses on the theoretical framework for mental retardation research in the Soviet Union with a differentiation between oligophrenics (who have organic brain damage) and the intellectually backward (or…