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Direct linkHuang, Ao; Komukai, Sho; Friede, Tim; Hattori, Satoshi – Research Synthesis Methods, 2021
Prospective registration of study protocols in clinical trial registries is a useful way to minimize the risk of publication bias in meta-analysis, and several clinical trial registries are available nowadays. However, they are mainly used as a tool for searching studies and information submitted to the registries has not been utilized as…
Descriptors: Publications, Bias, Meta Analysis, Selection
Günhan, Burak Kürsad; Röver, Christian; Friede, Tim – Research Synthesis Methods, 2020
Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number of studies is low, standard random-effects meta-analysis methods can lead to serious distortions because of such data sparsity. To overcome this, we suggest the use of…
Descriptors: Meta Analysis, Medical Research, Drug Therapy, Bayesian Statistics
