Undergraduate students may possess underdeveloped knowledge about water systems, particularly groundwater. The use of models and modeling have been employed in undergraduate classrooms to support students' learning about water. However, effective modeling requires spatial thinking skills, which undergraduate students may also need to develop.…

As part of COVID-19 preparedness, a student-developed, Android-based app was used as a pre-laboratory learning aid for a molecular modeling laboratory in a first-year general chemistry course. A worksheet activity with trigger codes and questions related to spatial features of transition metal complexes was designed. Using the Transition Metal…

Structures of 10 proteins from the Protein Data Bank were 3D printed as part of an undergraduate biochemistry teaching laboratory. All structures were successfully printed in either a space filling surface representation or a cartoon representation that traces the Ca carbon atoms of each amino acid residue. All structures were printed using…

We report our qualitative study of twenty-four students enrolled in the second-semester of a second-year undergraduate (sophomore-level) organic chemistry course, Organic Two. We asked the research participants to propose the product and electron-pushing mechanism of elementary mechanistic steps in the absence and presence of the corresponding…

We present an accessible implementation of augmented reality projections for the depiction of complex structures and motifs, including atomic orbitals and elemental allotropes. The utilization of a free, cross-platform-compatible, online database of these structures provides the access route for closer examination, either via augmented reality or…

Spatial intelligence is an essential skill commonly used within various fields of science. Students with low spatial abilities frequently struggle to identify, retrieve, and apply key complex abstract information presented as multiple representations to actual three-dimensional natural materials and phenomena. Spatial ability may be considered a…

In Anatomy and Physiology courses, students often struggle with visualizing structures, or processes, that occur at the cellular level, such as capillary exchange. Whenever available, models can be vital to students' understanding of a topic, particularly when they can be constructed by students in real time. To demonstrate capillary exchange to…

Molecular processes are highly complex, and are frequently difficult for high school and college students to comprehend. Because of the importance of visualization in learning, along with formative assessment of student understanding, utilization of 3D modeling software aids both educators and students alike. The activity described below required…

Visualizations and visual models are of substantial importance for science learning (Harrison and Treagust, 2000), and it seems impossible to study chemistry without visualizations. More specifically, the combination of visualizations with text is especially beneficial for learning when dual coding is fostered (Mayer, 2014). However, at the same…

Spatial reasoning is defined as the ability to generate, retain, and manipulate abstract visual images. In chemistry, spatial reasoning skills are typically taught using 2-D paper-based models, 3-D handheld models, and computerized models. These models are designed to aid student learning by integrating information from the macroscopic,…

Model-Based learning is a methodology that facilitates students' construction of scientific knowledge, which, sometimes, includes restructuring their mental models. Taking into consideration students' learning process, its aim is to promote a deeper understanding of phenomena's dynamics through the manipulation of models. Our aim was to ascertain…

Decades of research have demonstrated the correlation of spatial abilities to chemistry achievement and career selection. Nonetheless, reviews have highlighted the need and scarcity of explicit spatial instruction to promote spatial skills. Therefore, the goal of this literature review is to summarize what has been done during the past decade in…

In this activity, students manipulate three-dimensional molecular models of the Ala-Ala-Ala tripeptide, where Ala is alanine. They rotate bonds to show that the pairs of dihedral angles phi = 0 degrees, psi = 180 degrees, and phi = 0 degrees, psi = 0 degrees lead to unfavorable interactions among the main chain atoms of the tripeptide. This…

A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid…

An upper-division undergraduate laboratory experiment is described that explores the structure/function relationship of protein domains, namely leucine zippers, through a molecular graphics computer program and physical models fabricated by 3D printing. By generating solvent accessible surfaces and color-coding hydrophobic, basic, and acidic amino…