Drug repurposing refers to the process of discovering new therapeutic uses for existing medicines. Compared to traditional drug discovery, drug repurposing is attractive for its speed, cost, and reduced risk of failure. However, existing approaches for drug repurposing involve complex, computationally-intensive analytical methods that are not…

The thriving developer community has a significant impact on the widespread use of R software. To better understand this community, we conducted a study analyzing all R packages available on CRAN. We identified the most popular topics of R packages by text mining the package descriptions. Additionally, using network centrality measures, we…

Two approaches for the statistical analysis of social network generation are widely used; the tie-oriented exponential random graph model (ERGM) and the stochastic actor-oriented model (SAOM) or Siena model. While the choice for either model by empirical researchers often seems arbitrary, there are important differences between these models that…

This study shows that residual variation can cause problems related to scaling in exponential random graph models (ERGM). Residual variation is likely to exist when there are unmeasured variables in a model--even those uncorrelated with other predictors--or when the logistic form of the model is inappropriate. As a consequence, coefficients cannot…

The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not all, of the studies. We investigate the benefits of including varying proportions of IPD studies in an NMA. Several models have…

Self-determination theory (SDT) is one of the most well-known approaches to achievement motivation. However, the three basic psychological needs of SDT have not received equivalent attention in the literature: priority has been given to autonomy, followed by the need for competence, with research into relatedness lacking (Bachman and Stewart in…