In this article, I present a new multivariate regression model for analyzing outcomes with network dependence. The model is capable to account for two types of outcome dependence including the mean dependence that allows the outcome to depend on selected features of a known dependence network and the error dependence that allows the outcome to be…

Drug repurposing refers to the process of discovering new therapeutic uses for existing medicines. Compared to traditional drug discovery, drug repurposing is attractive for its speed, cost, and reduced risk of failure. However, existing approaches for drug repurposing involve complex, computationally-intensive analytical methods that are not…

Standard models for network meta-analysis simultaneously estimate multiple relative treatment effects. In practice, after estimation, these multiple estimates usually pass through a formal or informal selection procedure, eg, when researchers draw conclusions about the effects of the best performing treatment in the network. In this paper, we…

This study shows that residual variation can cause problems related to scaling in exponential random graph models (ERGM). Residual variation is likely to exist when there are unmeasured variables in a model--even those uncorrelated with other predictors--or when the logistic form of the model is inappropriate. As a consequence, coefficients cannot…

Time-course model-based network meta-analysis (MBNMA) has been proposed as a framework to combine treatment comparisons from a network of randomized controlled trials reporting outcomes at multiple time-points. This can explain heterogeneity/inconsistency that arises by pooling studies with different follow-up times and allow inclusion of studies…

The recent popularity of models that capture the dynamic coevolution of both network structure and behavior has driven the need for summary indices to assess the adequacy of these models to reproduce dynamic properties of scientific or practical importance. Whereas there are several existing indices for assessing the ability of the model to…

Network meta-analysis is used to simultaneously compare multiple treatments in a single analysis. However, network meta-analyses may exhibit inconsistency, where direct and different forms of indirect evidence are not in agreement with each other, even after allowing for between-study heterogeneity. Models for network meta-analysis with random…

The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not all, of the studies. We investigate the benefits of including varying proportions of IPD studies in an NMA. Several models have…

The purpose of this study is to explore the nature of complex adaptive systems (CAS) and network dynamics in international education (IE) programs in a U.S. higher education institution. I analyze the IE programs through a lens of complexity and network theories and ask how measures of engagement in complex networks affect performance in the IE…

Construction requires the knowledge and experience of craftsmen. The knowledge and experience is gained through local coordination and local adaption at points of installation, which classifies the work as complex production. Information generated at these points of installation can be valuable in understanding how and why workers make decisions,…