The set reduction algorithm is based on set theory and Boolean algebra rather than the graph-theoretic approach. Time trials with a small file of organic chemical structures indicate that the algorithm can be economically used for substructure (or complete structure) sequential searches on a file containing 30,000-50,000 computer-coded structures.…

Reports on a study which examined the relationship between spatial ability and performance in organic chemistry. Results indicated that students with high spatial scores did significantly better on questions requiring problem solving skills, as well as on those requiring the mental manipulation of two-dimensional representations of a molecule. (TW)