This article introduces an innovative sampling scheme, the median sampling (MS), utilizing individual observations over time to efficiently estimate the mean of a process characterized by a symmetric (non-uniform) probability distribution. The mean estimator based on MS is not only unbiased but also boasts enhanced precision compared to its simple…

Subjects with initially extreme observations upon remeasurement are found closer to the population mean. This tendency of observations toward the mean is called regression to the mean (RTM) and can make natural variation in repeated data look like real change. Studies, where subjects are selected on a baseline criterion, should be guarded against…