The aim of this study was to examine genetic variations underlying the early neurodevelopmental outcome of developmental disabilities (DDs). The study cohort consisted of 191 children with DDs. Diagnosis was assessed at baseline and at the index age (72-84 months). Exome sequencing was conducted and putative risk variants were identified.…

Extracorporeal life support, such as pediatric cardiac extracorporeal membrane oxygenation (ECMO), is associated with significant mortality and morbidity risk. This study evaluated cardiac ECMO survivors with central cannulation and found that 51.1% were discharged from the hospital. The study also revealed high rates of developmental delay…

Introduction: Down Syndrome (DS) is a common cause of intellectual disability with a possible glial-neuronal disruption. We assessed the effects of Cerebrolysin on the neurodevelopmental outcomes of infants with DS. Methods: This randomized controlled pilot trial included 64 infants with DS. They were allocated into a treatment group (n=32) who…

The majority of the research examining children with Autism Spectrum Disorder (ASD) and Williams Syndrome (WS) focus on the social domain while few have examined cognitive style and emotionality. Accordingly, this current study assessed the day-to-day cognitive and behavioral functioning of school-age children with ASD, WS, and neurotypical…

The aim was to evaluate the effects of a family-focused early intervention programme on the cognitive, motor, and language development of infants exposed to social and biological risks in the first year of life. Quasi-experimental randomized controlled trial (RBR-6ct969), with intervention (IG; n = 72) and control (CG; n = 170) groups. IG mothers…

From a preeminent researcher, this book looks at the key role of joint attention in both typical and atypical development. Peter C. Mundy shows that no other symptom dimension is more strongly linked to early identification and treatment of autism spectrum disorder (ASD). He synthesizes a wealth of knowledge on how joint attention develops, its…